Arizona State University (ASU) BME100 Introduction to Biomedical Engineering Midterm Practice Exam

The process of fouling in biomaterials primarily refers to the absorption of proteins or cells onto the surface of the material. This phenomenon occurs when biomaterials come into contact with biological fluids, such as blood or tissue. The interactions that take place at the surface can significantly influence the performance and biocompatibility of the material.

When proteins from the biological environment adhere to the material’s surface, they can alter how cells interact with that surface. This initial protein layer can serve as a platform for further cell adhesion and can influence the overall biomaterial behavior within the body. This fouling process is crucial to understand because it can impact the success of biomedical applications like implants, drug delivery systems, and tissue engineering scaffolds.

Understanding fouling is important for designing biomaterials that minimize undesirable interactions, such as thrombosis in blood-contacting devices, or promote appropriate cellular responses in tissue engineering applications.